This has been tested with OS-X 10.6 on a borrowed Intel Macbook with a core2 duo (intel) CPU.
First off.
Install OS-X (if you are starting with a bare machine)
install Xcode and X11 (they are on your install DVD)
Go to http://www.macports.org and download the appropriate release (DMG recommended) and install it (1.8.2 was current when i wrote this document)
Once macports is installed, open a terminal, and run the following commands:
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sudo port -v selfupdate
sudo port -v install gtkglext libglade2
Once the above steps complete SUCCESSFULLY, megatunix should be buildable. As of this writing, 4/11/2010, to compile megatunix requires a CVS checkout, 0.9.20 and later should hopefully be compilable from the tarball.
Goto http://msextra.com/forums/viewtopic.php?f=106&t=23548 and scroll down to "Downloading and compiling MegaTunix from CVS" and continue from that point.